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Congenital Heart Defect v0.279 ACTC1 Zornitza Stark Publications for gene: ACTC1 were set to 17947298; 31430208
Congenital Heart Defect v0.278 ACTC1 Zornitza Stark Classified gene: ACTC1 as Green List (high evidence)
Congenital Heart Defect v0.278 ACTC1 Zornitza Stark Gene: actc1 has been classified as Green List (High Evidence).
Congenital Heart Defect v0.277 ACTC1 Lilian Downie reviewed gene: ACTC1: Rating: GREEN; Mode of pathogenicity: None; Publications: PMID: 36945405; Phenotypes: Atrial septal defect 5 MIM#612794; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Congenital Heart Defect v0.217 ACTC1 Zornitza Stark commented on gene: ACTC1: E101K is multiply reported as pathogenic/likely pathogenic for HCM rather than CHD in ClinVar.

The 17bp deletion was inherited from a parent, with a very questionable affected status (posteriorly deviated interventricular septum).
Congenital Heart Defect v0.217 ACTC1 Chloe Stutterd reviewed gene: ACTC1: Rating: GREEN; Mode of pathogenicity: None; Publications: 17611253, 17947298; Phenotypes: Atrial septal defect, Ventricular septal defect; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted; Current diagnostic: yes
Congenital Heart Defect v0.163 ACTC1 Zornitza Stark Tag founder tag was added to gene: ACTC1.
Congenital Heart Defect v0.163 ACTC1 Zornitza Stark Classified gene: ACTC1 as Amber List (moderate evidence)
Congenital Heart Defect v0.163 ACTC1 Zornitza Stark Gene: actc1 has been classified as Amber List (Moderate Evidence).
Congenital Heart Defect v0.162 ACTC1 Zornitza Stark changed review comment from: Three families reported with congenital heart disease and variants in this gene. Note gene is also associated with cardiomyopathies.; to: Three families reported with congenital heart disease and variants in this gene. Note gene is also associated with cardiomyopathies.

Two of the families had the same founder variant.
Congenital Heart Defect v0.162 ACTC1 Zornitza Stark edited their review of gene: ACTC1: Changed rating: AMBER
Congenital Heart Defect v0.73 ACTC1 Zornitza Stark Marked gene: ACTC1 as ready
Congenital Heart Defect v0.73 ACTC1 Zornitza Stark Gene: actc1 has been classified as Green List (High Evidence).
Congenital Heart Defect v0.73 ACTC1 Zornitza Stark Phenotypes for gene: ACTC1 were changed from to Atrial septal defect 5, MIM# 612794
Congenital Heart Defect v0.72 ACTC1 Zornitza Stark Publications for gene: ACTC1 were set to
Congenital Heart Defect v0.71 ACTC1 Zornitza Stark Mode of inheritance for gene: ACTC1 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Congenital Heart Defect v0.70 ACTC1 Zornitza Stark reviewed gene: ACTC1: Rating: GREEN; Mode of pathogenicity: None; Publications: 17947298, 31430208; Phenotypes: Atrial septal defect 5, MIM# 612794; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Congenital Heart Defect v0.0 ACTC1 Zornitza Stark gene: ACTC1 was added
gene: ACTC1 was added to Congenital Heart Defect_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: ACTC1 was set to Unknown