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| Wilms Tumour Predisposition v0.35 | DIS3L2 | Zornitza Stark Marked gene: DIS3L2 as ready | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Wilms Tumour Predisposition v0.35 | DIS3L2 | Zornitza Stark Gene: dis3l2 has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Wilms Tumour Predisposition v0.35 | DIS3L2 | Zornitza Stark Phenotypes for gene: DIS3L2 were changed from to Wilms tumour, MONDO:0006058, DIS3L2-related | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Wilms Tumour Predisposition v0.34 | DIS3L2 | Zornitza Stark Publications for gene: DIS3L2 were set to | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Wilms Tumour Predisposition v0.33 | DIS3L2 | Zornitza Stark Mode of inheritance for gene: DIS3L2 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Wilms Tumour Predisposition v0.32 | DIS3L2 | Zornitza Stark reviewed gene: DIS3L2: Rating: GREEN; Mode of pathogenicity: None; Publications: ; Phenotypes: Wilms tumour, MONDO:0006058, DIS3L2-related; Mode of inheritance: MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Wilms Tumour Predisposition v0.32 | DIS3L2 | Laura Raiti changed review comment from: 5 unrelated patients in an unselected cohort of children between 2015 - 2020 identified to have germline heterozygous pathogenic variant in DIS3L2 (two truncating variants, 3 deletions of exon 9). 4 of 5 had a second somatic hit in Wilms Tumour tissue.; to: 5 unrelated patients in an unselected cohort of children between 2015 - 2020 identified to have germline heterozygous pathogenic variant in DIS3L2 (two truncating variants, 3 deletions of exon 9). 4 of 5 had a second somatic hit in Wilms Tumour tissue. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Wilms Tumour Predisposition v0.32 | DIS3L2 | Laura Raiti reviewed gene: DIS3L2: Rating: ; Mode of pathogenicity: None; Publications: 35230882; Phenotypes: Wilms Tumour; Mode of inheritance: None | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Wilms Tumour Predisposition v0.0 | DIS3L2 |
Zornitza Stark gene: DIS3L2 was added gene: DIS3L2 was added to Wilms Tumour Predisposition_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services Mode of inheritance for gene: DIS3L2 was set to Unknown |
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