| Date | Panel | Item | Activity | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Transplant Co-Morbidity Superpanel v0.13 | NUDT15 | Bryony Thompson Marked gene: NUDT15 as ready | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Transplant Co-Morbidity Superpanel v0.13 | NUDT15 | Bryony Thompson Gene: nudt15 has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Transplant Co-Morbidity Superpanel v0.13 | NUDT15 | Bryony Thompson Classified gene: NUDT15 as Green List (high evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Transplant Co-Morbidity Superpanel v0.13 | NUDT15 | Bryony Thompson Gene: nudt15 has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Transplant Co-Morbidity Superpanel v0.4 | NUDT15 |
Claire Fryer-Smith gene: NUDT15 was added gene: NUDT15 was added to Transplant Co-Morbidity Superpanel. Sources: Expert list Mode of inheritance for gene: NUDT15 was set to Other Publications for gene: NUDT15 were set to 26878724 Phenotypes for gene: NUDT15 were set to Thiopurines, poor metabolism of, 2 MIM# 616903 Review for gene: NUDT15 was set to GREEN Added comment: It is involved in guidelines for thiopurines including mercaptopurine and azathioprine. https://www.pharmgkb.org/gene/PA134963132 Pathogenic variants in NUDT15 result in poor metabolism of thiopurines that was significantly associated with thiopurine-induced leukopenia. The NUDT15 deficiency trait follows an additive genetic mode of inheritance, with the severity of the phenotype proportional to the cumulative number of risk alleles in NUDT15. Mechanistically, NUDT15 inactivated thiopurine metabolites and decreased thiopurine cytotoxicity in vitro, and patients with defective NUDT15 alleles showed excessive levels of thiopurine active metabolites and toxicity. (PMID: 26878724). Sources: Expert list |
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