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| Early-onset Dementia v0.73 | TET2 | Zornitza Stark Marked gene: TET2 as ready | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Early-onset Dementia v0.73 | TET2 | Zornitza Stark Gene: tet2 has been classified as Red List (Low Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Early-onset Dementia v0.73 | TET2 |
Zornitza Stark gene: TET2 was added gene: TET2 was added to Early-onset Dementia. Sources: Literature Mode of inheritance for gene: TET2 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Publications for gene: TET2 were set to 32330418; 31943063 Phenotypes for gene: TET2 were set to Dementia Review for gene: TET2 was set to RED Added comment: Association study (PMID 32330418) found enrichment of non-coding and LoF TET2 variants in cohort of individuals with early onset dementia, unclear if this is monogenic or polygenic contribution. PMID: 31943063 - Li et al 2020 - functional studies in mice show that Tet2 depletion in the hippocampus exacerbates Alzheimer disease pathology and cognitive dysfunction at early disease stages. Sources: Literature |
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