PanelApp (test)
  1. Genes and Genomic Entities
  2. KRAS

KRAS

KRAS proto-oncogene, GTPase
OMIM: 190070, Gene2Phenotype

21 panels

Panel Reviews Mode of inheritance Details
21 panels

Green KRAS in Congenital Heart Defect


Level 2: Cardiovascular disorders
Version 0.418

review Unknown
Sources
  • Victorian Clinical Genetics Services
  • Expert Review Green

Green KRAS in Craniosynostosis


Level 2: Dysmorphic and congenital abnormality syndromes
Version 1.68

review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Literature
Phenotypes
  • Noonan syndrome

Green KRAS in Hydrops fetalis


Level 2: Dysmorphic and congenital abnormality syndromes
Version 0.313

review Unknown
Sources
  • Victorian Clinical Genetics Services
  • Expert Review Green

Green KRAS in Macrocephaly_Megalencephaly


Level 2: Dysmorphic and congenital abnormality syndromes
Version 0.140

review Unknown
Sources
  • Victorian Clinical Genetics Services
  • Expert Review Green

Green KRAS in Mendeliome


Version 1.1902

review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Victorian Clinical Genetics Services
Phenotypes
  • Cardiofaciocutaneous syndrome 2 615278
  • Noonan syndrome 3 609942
  • RAS-associated autoimmune leukoproliferative disorder 614470
  • Schimmelpenning-Feuerstein-Mims syndrome, somatic mosaic 163200

Green KRAS in Cancer Predisposition_Paediatric


Level 2: Cancer
Version 0.131

review Unknown
Sources
  • Victorian Clinical Genetics Services
  • Expert Review Green

Green KRAS in Rasopathy


Level 2: Dysmorphic and congenital abnormality syndromes
Version 0.105

review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Victorian Clinical Genetics Services
Phenotypes
  • Noonan syndrome 3, MIM# 609942
  • Cardiofaciocutaneous syndrome 2, MIM# 615278

Green KRAS in Genetic Epilepsy


Level 2: Neurology and neurodevelopmental disorders
Version 1.33

Component of the following Super Panels:

  • Progressive Neurological Conditions

    		•  review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Green
    • Victorian Clinical Genetics Services
    • Australian Genomics Health Alliance Epilepsy Flagship
    Phenotypes
    • Oculoectodermal syndrome, somatic MIM#600268
    • Schimmelpenning-Feuerstein-Mims syndrome, somatic mosaic MIM#163200
    Tags
    • somatic

    Green KRAS in Callosome


    Level 2: Neurology and neurodevelopmental disorders
    Version 0.522

    		review Unknown
    Sources
    • Victorian Clinical Genetics Services
    • Expert Review Green

    Green KRAS in Intellectual disability syndromic and non-syndromic


    Level 2: Neurology and neurodevelopmental disorders
    Version 0.6063

    		review Unknown
    Sources
    • Genetic Health Queensland
    • Expert Review Green

    Red KRAS in Vascular Malformations_Germline


    Level 2: Cardiovascular disorders
    Version 1.11

    Component of the following Super Panels:

  • Vascular Malformations SuperPanel

    		•  review Other
    Sources
    • Expert Review Red
    • Expert list
    Phenotypes
    • Arteriovenous malformation of the brain, somatic 108010
    • Vascular malformation
    Tags
    • somatic

    Red KRAS in TCGA_PANCAN_2018


    Version 0.2

    		review Other
    Sources
    • TCGA_PANCAN_2018
    Phenotypes
    • RAS-associated autoimmune leukoproliferative disorder
    • Noonan syndrome 3

    Green KRAS in Lymphoedema_syndromic

    Level 3: Lymphatic Disorders
    Level 2: Cardiovascular disorders
    Version 0.12

    Component of the following Super Panels:

  • Vascular Malformations SuperPanel

    		•  review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Green
    • Expert Review
    Phenotypes
    • Cardiofaciocutaneous syndrome 2 615278
    • Noonan syndrome 3 609942

    Green KRAS in Vascular Malformations_Somatic


    Level 2: Cardiovascular disorders
    Version 1.13

    Component of the following Super Panels:

  • Vascular Malformations SuperPanel

    		•  review Other
    Sources
    • Expert Review Green
    • Expert list
    • Expert list
    Phenotypes
    • Arteriovenous malformation of the brain, somatic 108010
    • Vascular malformation
    Tags
    • somatic

    Green KRAS in Cardiomyopathy_Paediatric


    Level 2: Cardiovascular disorders
    Version 0.192

    		review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • South West GLH
    • NHS GMS
    • Expert List
    • London South GLH
    Phenotypes
    • Cardiofaciocutaneous syndrome 2, MIM# 615278
    • Noonan syndrome 3, MIM# 609942

    Green KRAS in Additional findings_Paediatric


    Level 2: Screening
    Version 0.278

    		review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • BabySeq Category A gene
    • Expert Review Green
    Phenotypes
    • Noonan syndrome

    Green KRAS in Incidentalome_PREGEN_DRAFT


    Version 0.43

    		review Unknown
    Sources
    • NSW Health Pathology
    • Expert Review Green

    Green KRAS in Mosaic skin disorders


    Level 2: Dermatological disorders
    Version 1.12

    Component of the following Super Panels:

  • Vascular Malformations SuperPanel

    		•  review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • Genomics England PanelApp
    • NHS GMS
    Phenotypes
    • Epidermal naevi
    • Schimmelpenning syndrome
    Tags
    • somatic

    Green KRAS in Growth failure


    Version 1.76

    		review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • Genomics England PanelApp
    • Victorian Clinical Genetics Services
    Phenotypes
    • Noonan syndrome 3, MIM# 609942
    • Cardiofaciocutaneous syndrome 2, MIM# 615278

    Green KRAS in Fetal anomalies


    Version 1.255

    		review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • Genomics England PanelApp
    • Victorian Clinical Genetics Services
    Phenotypes
    • Noonan syndrome 3, MIM# 609942
    • Cardiofaciocutaneous syndrome 2, MIM# 615278

    Red KRAS in BabyScreen+ newborn screening


    Level 2: Screening
    Version 1.114

    		review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Red
    • BabySeq Category A gene
    Phenotypes
    • Noonan syndrome 3, MIM# 609942
    • Cardiofaciocutaneous syndrome 2, MIM# 615278